Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages.

Brain research - 25 Mar 2011

Nakajima Mitsunari, Matsuda Keiko, Miyauchi Naho, Fukunaga Yasuyoshi, Watanabe Sono, Okuyama Satoshi, Pérez Juan, Fernández-Llebrez Pedro, Shen Jie, Furukawa Yoshiko

Abstract excerpt

Presenilin-1 (PS1) is a transmembrane protein that is in many cases responsible for the development of familial Alzheimer's disease. PS1 is widely expressed in embryogenesis and is essential for neurogenesis, somitogenesis, angiogenesis, and cardiac morphogenesis. To further investigate the role of PS1 in the brain, we inactivated the PS1 gene in Wnt1 cell lineages using the Cre-loxP recombination system. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Cerebral Ventricles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebrospinal Fluid

Share to Homeostasis

Share to Hydrocephalus

Share to Nervous System Malformations

Share to Presenilin-1

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 21262207
DOI: 10.1016/j.brainres.2011.01.048
PMCID: PMC3418702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages.PMID 21262207Read ↗

Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineagesSemantic proximity Read ↗

Skeletal and CNS defects in Presenilin-1-deficient mice.Semantic proximity Read ↗

Hydrocephalus in Connection to Genetic Mutation in Cranial Neural Crest Cells.Semantic proximity Read ↗

Presenilin 1 is essential for cardiac morphogenesis.Semantic proximity Read ↗

Absence of posterior commissure and sub-commissural organ precedes encephalocele development in a new mouse modelSemantic proximity Read ↗

Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organSemantic proximity Read ↗

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.Semantic proximity Read ↗

Molecular Biology of Pediatric Hydrocephalus and Hydrocephalus-related Diseases.Semantic proximity Read ↗

Gain-of-function mutations in Trim71 linked to congenital hydrocephalus.Semantic proximity Read ↗

Congenital hydrocephalus in genetically engineered mice.Semantic proximity Read ↗

Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus.Semantic proximity Read ↗

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.