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Article

Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly.

Human molecular genetics - 15 Jun 2007

Huang Xi, Litingtung Ying, Chiang Chin

Abstract excerpt

Holoprosencephaly (HPE) is the most common developmental anomaly of the human forebrain, and in its severe form, the cerebral hemispheres fail to completely separate into two distinct halves. Although disruption of ventral forebrain induction is thought to underlie most HPE cases, a subset of HPE patients exhibits preferential dysgenesis of forebrain dorsal midline structures with unknown etiology. In this study,...

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Identifiers

PMID: 17468181
DOI: 10.1093/hmg/ddm096

Genes

SHH

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