Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity.

Stem cell reports - 9 Dec 2014

Moya Noel, Cutts Josh, Gaasterland Terry, Willert Karl, Brafman David A

Abstract excerpt

Neural progenitor cells (NPCs) derived from human pluripotent stem cells (hPSCs) are a multipotent cell population that is capable of nearly indefinite expansion and subsequent differentiation into the various neuronal and supporting cell types that comprise the CNS. However, current protocols for differentiating NPCs toward neuronal lineages result in a mixture of neurons from various regions of the CNS. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cluster Analysis

Share to Gene Expression Profiling

Share to Immunophenotyping

Share to Neural Stem Cells

Share to Pluripotent Stem Cells

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 25458891
DOI: 10.1016/j.stemcr.2014.10.004
PMCID: PMC4264562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity.PMID 25458891Read ↗

Global Transcriptional Analyses of the Wnt-Induced Development of Neural Stem Cells from Human Pluripotent Stem CellsSemantic proximity Read ↗

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate GyrusSemantic proximity Read ↗

Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cellsSemantic proximity Read ↗

Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cellsSemantic proximity Read ↗

Adult Human Brain Neural Progenitor Cells (NPCs) and Fibroblast-Like Cells Have Similar Properties In Vitro but Only NPCs Differentiate into NeuronsSemantic proximity Read ↗

Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells.Semantic proximity Read ↗

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue OriginsSemantic proximity Read ↗

Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial InteractionsSemantic proximity Read ↗

Human-specific progenitor sub-domain contributes to extended neurogenesis and increased motor neuron productionSemantic proximity Read ↗

Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.Semantic proximity Read ↗

Changes in neural progenitor lineage constituent during astrocytic differentiation of human iPSCsSemantic proximity Read ↗

Signal requirement for cortical potential of transplantable human neuroepithelial stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.