Article

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

2025-09-17

Abstract excerpt

The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biology, how GATA1 co-regulates divergent cell fates remains only partially characterized. We previously described that loss of Stag2, a member of the cohesin complex and a recurrent mutational target in myelodysplastic s...

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Literature Corpus work: d1513b37-a769-5e1d-af81-5750e7271568
DOI: 10.1101/2025.09.15.676332

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