Article

Human iPSCs-based modeling unveils chromatin remodeling induced by SETBP1 mutation as a potential initiating factor in GATA2 deficiency

2024-09-04

Abstract excerpt

<title>Abstract</title> Patients with GATA2 deficiency are predisposed to developing myelodysplastic syndrome (MDS), which can progress to acute myeloid leukemia (AML). This progression is often associated with the acquisition of additional cytogenetic and somatic alterations. Mutations in SETBP1 and ASXL1 genes are frequently observed in pediatric GATA2 patients, but their roles in disease progression remain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4014df2b-9544-58ff-9c30-499ce352c876
DOI: 10.21203/rs.3.rs-4984522/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human iPSCs-based modeling unveils chromatin remodeling induced by SETBP1 mutation as a potential initiating factor in GATA2 deficiencyDOI 10.21203/rs.3.rs-4984522/v1Read

CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness.Semantic proximity Read

The Clinical Spectrum, Diagnosis, and Management of GATA2 DeficiencySemantic proximity Read

GATA2 deficiency and MDS / AML : Experimental strategies for disease modelling and future therapeutic prospectsSemantic proximity Read

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.Semantic proximity Read

Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in Gata2 haploinsufficiencySemantic proximity Read

GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine.Semantic proximity Read

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.Semantic proximity Read

Gata2a maintains cebpa and npm1a in haematopoietic stem cells to sustain lineage differentiation and genome stabilitySemantic proximity Read

Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene U2af1Semantic proximity Read

A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS ProgressionSemantic proximity Read

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesSemantic proximity Read

GATA2 deficiency and related myeloid neoplasms.Semantic proximity Read