Article

Cancer risks for<i>MSH6</i>pathogenic variant carriers

2025-02-18

Abstract excerpt

<h4>Introduction</h4> Lynch syndrome (LS) is a hereditary cancer syndrome caused by (likely) pathogenic variants (LP/P) in DNA mismatch repair genes, including MSH6 . It is associated with elevated lifetime risks for colorectal cancer (CRC), endometrial cancer (EC), and other malignancies. However, cancer risks specific to MSH6 -associated LS, particularly for non-colorectal cancers, remain poorly defined. This st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d146cc54-6ba8-500e-9b80-02461f480d03
DOI: 10.1101/2025.02.15.25322330

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cancer risks for<i>MSH6</i>pathogenic variant carriersDOI 10.1101/2025.02.15.25322330Read

Risks of Lynch Syndrome Cancers for MSH6 Mutation CarriersSemantic proximity Read

Cancer risks in Lynch syndrome carriers: a systematic review and meta-analysis.Semantic proximity Read

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome DatabaseSemantic proximity Read

Estimating cancer risk in carriers of Lynch syndrome variants in UK BiobankSemantic proximity Read

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillanceSemantic proximity Read

Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions.Semantic proximity Read

Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch SyndromeSemantic proximity Read

Prevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancersSemantic proximity Read

Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.Semantic proximity Read

Cancer-risk by family history and mismatch-repair mutation in Lynch syndrome.Semantic proximity Read

Update on Lynch syndrome genomics.Semantic proximity Read

Cancer Risks for<i>MLH</i><i>1</i>and<i>MSH</i><i>2</i>Mutation CarriersSemantic proximity Read