Article
Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions.
Gynecologic oncology - 1 Nov 2007
Lancaster Johnathan M, Powell C Bethan, Kauff Noah D, Cass Ilana, Chen Lee-May, Lu Karen H, Mutch David G, Berchuck Andrew, Karlan Beth Y, Herzog Thomas J
Abstract excerpt
Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast/Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk ovarian cancer. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2 or MSH6, associated with the Lynch/Hereditary Non-Polyposis Colorectal Cancer (HNPCC) syndrome, have up...
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