Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Update on Lynch syndrome genomics.

Familial cancer - 1 Jul 2016

Peltomäki Päivi

Abstract excerpt

Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6, and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of the most prevalent hereditary cancer syndromes in man and accounts for 1-3 % of unselected colorectal carcinomas and some 15 % of those with microsatellite instability and/or absent MMR protein. The International Society for Gastrointestinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Mismatch Repair
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Microsatellite Instability

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 26873718
DOI: 10.1007/s10689-016-9882-8
PMCID: PMC4901089

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Update on Lynch syndrome genomics.PMID 26873718Read ↗

New Insights into Lynch Syndrome: A Narrative Review.Semantic proximity Read ↗

Lynch syndrome in the 21st century: clinical perspectives.Semantic proximity Read ↗

The changing landscape of Lynch syndrome due to PMS2 mutations.Semantic proximity Read ↗

Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategiesSemantic proximity Read ↗

Recent advances in Lynch syndromeSemantic proximity Read ↗

Mismatch repair genes in Lynch syndrome: a reviewSemantic proximity Read ↗

Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges (Review)Semantic proximity Read ↗

Current clinical topics of Lynch syndrome.Semantic proximity Read ↗

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndromeSemantic proximity Read ↗

Clinical and Molecular Characterization of Brazilian Patients Suspected to Have Lynch SyndromeSemantic proximity Read ↗

Review article: Lynch Syndrome—a mechanistic and clinical management updateSemantic proximity Read ↗

Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.