Article

Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank

2023-11-10

Abstract excerpt

<h4>Background</h4> Lynch syndrome (LS) is an inherited cancer predisposition syndrome caused by genetic variants affecting DNA mismatch repair (MMR) genes MLH1 , MSH2 , MSH6 , and PMS2 . Cancer risk in LS is estimated from cohorts of individuals ascertained by family history of cancer, which is known to upwardly bias estimates. <h4>Methods</h4> The InSiGHT Database classifies MMR gene variants by pathogenicity th...

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Literature Corpus work: 6c543956-bcfd-5668-89b1-cc3dd932549d
DOI: 10.1101/2023.11.10.23298308

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