Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer Risks for<i>MLH</i><i>1</i>and<i>MSH</i><i>2</i>Mutation Carriers

18 Dec 2012

Abstract excerpt

We studied 17,576 members of 166 MLH1 and 224 MSH2 mutation-carrying families from the Colon Cancer Family Registry. Average cumulative risks of colorectal cancer (CRC), endometrial cancer (EC), and other cancers for carriers were estimated using modified segregation analysis conditioned on ascertainment criteria. Heterogeneity in risks was investigated using a polygenic risk modifier. Average CRC cumulative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23255516
DOI: 10.1002/humu.22262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer Risks for<i>MLH</i><i>1</i>and<i>MSH</i><i>2</i>Mutation CarriersPMID 23255516Read ↗

Cancer risks for<i>MSH6</i>pathogenic variant carriersSemantic proximity Read ↗

Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in OntarioSemantic proximity Read ↗

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study.Semantic proximity Read ↗

Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome.Semantic proximity Read ↗

Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Risks of Lynch Syndrome Cancers for MSH6 Mutation CarriersSemantic proximity Read ↗

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome DatabaseSemantic proximity Read ↗

Cancer Risks for PMS2-Associated Lynch Syndrome.Semantic proximity Read ↗

Accurate classification of <i>MLH1/MSH2</i> missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)Semantic proximity Read ↗

Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.Semantic proximity Read ↗

Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors.Semantic proximity Read ↗

Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.