Article
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.
JAMA - 8 Jun 2011
Bonadona Valérie, Bonaïti Bernard, Olschwang Sylviane, Grandjouan Sophie, Huiart Laetitia, Longy Michel, Guimbaud Rosine, Buecher Bruno, Bignon Yves-Jean, Caron Olivier, Colas Chrystelle, Noguès Catherine, Lejeune-Dumoulin Sophie, Olivier-Faivre Laurence, Polycarpe-Osaer Florence, Nguyen Tan Dat, Desseigne Françoise, Saurin Jean-Christophe, Berthet Pascaline, Leroux Dominique, Duffour Jacqueline, Manouvrier Sylvie, Frébourg Thierry, Sobol Hagay, Lasset Christine, Bonaïti-Pellié Catherine
Abstract excerpt
CONTEXT: Providing accurate estimates of cancer risks is a major challenge in the clinical management of Lynch syndrome. OBJECTIVE: To estimate the age-specific cumulative risks of developing various tumors using a large series of families with mutations of the MLH1, MSH2, and MSH6 genes. DESIGN, SETTING, AND PARTICIPANTS: Families with Lynch syndrome enrolled between January 1, 2006, and December 31, 2009, from...
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