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Article

Cancer risks in Lynch syndrome carriers: a systematic review and meta-analysis.

Journal of the National Cancer Institute - 1 Apr 2026

Campoy Séphora, Drouet Youenn, Rochefort Pauline, Bonadona Valérie, Lasset Christine

Abstract excerpt

BACKGROUND: Lynch syndrome (LS), caused by pathogenic variants (PVs) in mismatch repair genes, increases the risk of several cancers. Surveillance guidelines vary internationally due to inconsistent risk estimates. This study refines cancer risk estimates by gene, sex, and age to support personalized recommendations. METHODS: This meta-analysis included studies reporting cumulative cancer risks in genetically...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

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Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

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Source

Identifiers

PMID: 41389835
DOI: 10.1093/jnci/djaf349

Genes

MLH1
MSH2
PMS2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Cancer risks in Lynch syndrome carriers: a systematic review and meta-analysis.PMID 41389835Read ↗

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