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C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes

26 Apr 2023

Abstract excerpt

Transmembrane protein 106B (TMEM106B) is a tightly regulated glycoprotein predominantly localized to endosomes and lysosomes. Genetic studies have implicated TMEM106B haplotypes in the development of multiple neurodegenerative diseases with the strongest effect in frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), especially in progranulin (GRN) mutation carriers. Recently, cryo-electron...

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PMID: 37100087
DOI: 10.1093/brain/awad133

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C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypesPMID 37100087Read ↗

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