Article

A novel mechanism of regulation of the transcription factor GLI3 by toll-like receptor signaling

2021-01-05

Abstract excerpt

The transcription factor GLI3 is a member of the GLI family and has been shown to be regulated by canonical hedgehog (HH) signaling through smoothened (SMO). Little is known about SMO-independent regulation of GLI3. Here, we identify TLR signaling as a novel pathway regulating GLI3 expression. We show that GLI3 expression is induced by LPS/TLR4 in human monocyte cell lines and peripheral blood CD14 + cells. Furth...

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Literature Corpus work: d1323adb-ac65-5a58-b738-b09fb9c98f85
DOI: 10.1101/2021.01.01.424866

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