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Article

PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

FEBS letters - 16 Jul 2004

Zhang Jun, Xu Liang-Guo, Han Ke-Jun, Wei Xudong, Shu Hong-Bing

Abstract excerpt

The TIR domain-containing adapter protein TRIP is critically involved in TLR3-induced IFN-beta production through activation of NF-kappaB and ISRE. In addition, TRIF also induces apoptosis when overexpressed in 293 cells. In this report, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, interacts with TRIP, IRF-3 and IRF-7. In reporter gene assays, PIASy dramatically inhibits TRIF-induced...

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Source

Identifiers

PMID: 15251447
DOI: 10.1016/j.febslet.2004.05.081

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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