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Article

Theiler's virus infection induces TLR3‐dependent upregulation of TLR2 critical for proinflammatory cytokine production

3 Feb 2009

Abstract excerpt

Theiler's murine encephalomyelitis virus (TMEV) infection directly induces many proinflammatory genes, including type I interferon (IFN) and a variety of cytokine genes. These virus-induced cytokines are a critical factor in developing TMEV-induced demyelinating disease. We have previously reported that the major activation signal for the cytokine genes is mediated via TLR3. In this study, we describe that TLR2...

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PMID: 19191335
DOI: 10.1002/glia.20843

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