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Article

ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2024

Li Jiaoduan, Cao Dongyan, Jiang Lixin, Zheng Yiwen, Shao Siyuan, Zhuang Ai, Xiang Dongxi

Abstract excerpt

PURPOSE: Uveal melanoma (UM) with BAP1 inactivating mutations has a high risk of metastasis, but the mechanism behind BAP1 deficiency driving UM metastasis is unknown. METHODS: We analyzed the single-cell RNA sequencing (scRNA-Seq) data comprised primary and metastatic UM with or without BAP1 mutations (MUTs) to reveal inter- and intra-tumor heterogeneity among different groups. Then, an immune-competent mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38150154
DOI: 10.1007/s13402-023-00908-4
PMCID: PMC12974008

Genes

BAP1
ICAM1
ITGB2
ADAM8
ATF3
CAV2
CDKN1A
ENO1
GDF15
ITGA5
LOXL2
PGK1
VCAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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