Article

Structural characterization of a breast cancer-associated mutation in caveolin-1

2022-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Caveolin-1 (CAV1) is a membrane sculpting protein that oligomerizes to generate flask-shaped invaginations of the plasma membrane known as caveolae. Mutations in CAV1 have been linked to multiple diseases in humans. Such mutations often interfere with oligomerization and the intracellular trafficking processes required for successful caveolae assembly, but the molecular mechanisms underlying the...

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Literature Corpus work: d10d00d6-5291-52e7-a8e3-5fca79e16e17
DOI: 10.1101/2022.05.23.493104

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