Article
Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation.
Cell cycle (Georgetown, Tex.) - 1 May 2009
Mercier Isabelle, Bryant Kelly G, Sotgia Federica, Bonuccelli Gloria, Witkiewicz Agnieszka K, Dasgupta Abhijit, Jasmin Jean-François, Pestell Richard G, Lisanti Michael P
Abstract excerpt
Caveolin-1 (Cav-1) mutations, such as P132L, are associated with ER-positive human breast cancers. However, no immunohistochemical methods have yet been described to predict the presence of Cav-1 mutations in human breast cancer. Since the P132L mutation acts in a dominant-negative fashion and causes the mis-localization of Cav-1 in cultured cells in vitro, we hypothesized that of patients carrying this mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.