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Article

Single molecule network analysis identifies structural changes to caveolae and scaffolds due to mutation of the caveolin-1 scaffolding domain.

Scientific reports - 8 Apr 2021

Wong Timothy H, Khater Ismail M, Joshi Bharat, Shahsavari Mona, Hamarneh Ghassan, Nabi Ivan R

Abstract excerpt

Caveolin-1 (CAV1), the caveolae coat protein, also associates with non-caveolar scaffold domains. Single molecule localization microscopy (SMLM) network analysis distinguishes caveolae and three scaffold domains, hemispherical S2 scaffolds and smaller S1B and S1A scaffolds. The caveolin scaffolding domain (CSD) is a highly conserved hydrophobic region that mediates interaction of CAV1 with multiple effector...

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Caveolin 1
Cell Line
Mutation
Protein Conformation
Protein Domains

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PMID: 33833286
DOI: 10.1038/s41598-021-86770-6
PMCID: PMC8032680

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