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Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in the assembly of oligomeric complexes.

The Journal of biological chemistry - 1 Apr 2023

Han Bing, Gulsevin Alican, Connolly Sarah, Wang Ting, Meyer Brigitte, Porta Jason, Tiwari Ajit, Deng Angie, Chang Louise, Peskova Yelena, Mchaourab Hassane S, Karakas Erkan, Ohi Melanie D, Meiler Jens, Kenworthy Anne K

Abstract excerpt

Caveolin-1 (CAV1) is a membrane-sculpting protein that oligomerizes to generate flask-shaped invaginations of the plasma membrane known as caveolae. Mutations in CAV1 have been linked to multiple diseases in humans. Such mutations often interfere with oligomerization and the intracellular trafficking processes required for successful caveolae assembly, but the molecular mechanisms underlying these defects have...

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Caveolae
Caveolin 1
Caveolins
Cell Membrane
Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Protein Subunits

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PMID: 36870682
DOI: 10.1016/j.jbc.2023.104574
PMCID: PMC10124911

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