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Article

Absence of the caveolin-1 P132L mutation in cancers of the breast and other organs.

The Journal of molecular diagnostics : JMD - 1 Sept 2010

Koike Shinya, Kodera Yasuhiro, Nakao Akimasa, Iwata Hiroji, Yatabe Yasushi

Abstract excerpt

Caveolin-1 belongs to a family of scaffolding proteins, and the P132L point mutation of this gene has been found in up to 16% of all examined breast cancers. Subsequent studies have revealed that the P132L mutation exerts a dominant negative effect through misfolding during caveolin-1 oligomerization. However, this mutation has not been validated in other series of breast cancer samples. Contradictory to the...

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Identifiers

PMID: 20581046
DOI: 10.2353/jmoldx.2010.090180
PMCID: PMC2928437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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