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Proteostatic regulation of caveolins avoids premature oligomerisation and preserves ER homeostasis

2022-04-24

Abstract excerpt

Caveolin-1 (CAV1) and CAV3 are membrane sculpting proteins driving formation of plasma membrane caveolae. Caveola formation is unique as it requires oligomerisation of newly synthesised caveolins through the biosynthetic-secretory pathway. Here, we combine structural, biochemical, and microscopy analyses to examine the early proteostasis of caveolin family members and mutants. We describe striking trafficking diff...

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Literature Corpus work
18d8a8f6-ba01-57c1-9f4f-419ef1c8143e
DOI
10.1101/2022.04.24.489297
Open publication

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Proteostatic regulation of caveolins avoids premature oligomerisation and preserves ER homeostasisDOI 10.1101/2022.04.24.489297
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