Article

Mammalian HEMK1 Methylates Glutamine Residue of the GGQ Motif of Mitochondrial Release Factors

2021-11-17

Abstract excerpt

<title>Abstract</title> <p>Despite limited reports on glutamine methylation, methylated glutamine is found to be highly conserved in a "GGQ" motif in both prokaryotes and eukaryotes. In bacteria, glutamine methylation of peptide chain release factors 1/2 (RF1/2) by the enzyme PrmC is essential for translational termination and transcript recycling. Two PrmC homologs, HEMK1 and HEMK2, are found in mammals. In cont...

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Literature Corpus work: d0fddd8d-46b8-5a0d-9a90-40a750bbdd19
DOI: 10.21203/rs.3.rs-1049003/v1

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