Article
A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins.
Molecular and cellular biology - 1 Jul 1996
Henry M F, Silver P A
Abstract excerpt
RNA-binding proteins play many essential roles in the metabolism of nuclear pre-mRNA. As such, they demonstrate a myriad of dynamic behaviors and modifications. In particular, heterogeneous nuclear ribonucleoproteins (hnRNPs) contain the bulk of methylated arginine residues in eukaryotic cells. We have identified the first eukaryotic hnRNP-specific methyltransferase via a genetic screen for proteins that interact...
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