Article
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.
The Journal of biological chemistry - 26 Dec 2003
Serero Alexandre, Giglione Carmela, Sardini Alessandro, Martinez-Sanz Juan, Meinnel Thierry
Abstract excerpt
Dedicated machinery for N-terminal methionine excision (NME) was recently identified in plant organelles and shown to be essential in plastids. We report here the existence of mitochondrial NME in mammals, as shown by the identification of cDNAs encoding specific peptide deformylases (PDFs) and new methionine aminopeptidases (MAP1D). We cloned the two full-length human cDNAs and showed that the N-terminal domains...
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