Article

Recurrent exon-deleting activating mutations in <i>AHR</i> act as drivers of urinary tract cancer

2021-11-10

Abstract excerpt

Bladder cancer has a high recurrence rate and low survival of advanced stage patients. Few genetic drivers of bladder cancer have thus far been identified. We performed in-depth structural variant analysis on whole-genome sequencing data of 206 metastasized urinary tract cancers. In ~10% of the patients, we identified recurrent in-frame deletions of exons 8 and 9 in the aryl hydrocarbon receptor gene ( AHR Δe8-9...

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Literature Corpus work: d0fce7d6-47c4-541c-8a4f-21cec5d4518d
DOI: 10.1101/2021.11.09.468005

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