Article
FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias.
European urology - 1 Jan 2023
Shi Ming-Jun, Fontugne Jacqueline, Moreno-Vega Aura, Meng Xiang-Yu, Groeneveld Clarice, Dufour Florent, Kamoun Aurélie, Viborg Lindskrog Sia, Cabel Luc, Krucker Clémentine, Rapinat Audrey, Dunois-Larde Claire, Lepage May-Linda, Chapeaublanc Elodie, Levrel Olivier, Dixon Victoria, Lebret Thierry, Almeida Anna, De Reynies Aurélien, Rochel Natacha, Dyrskjøt Lars, Allory Yves, Radvanyi François, Bernard-Pierrot Isabelle
Abstract excerpt
BACKGROUND: Bladder cancer (BCa) is more common in men and presents differences in molecular subtypes based on sex. Fibroblast growth factor receptor 3 (FGFR3) mutations are enriched in the luminal papillary muscle-invasive BCa (MIBC) and non-MIBC subtypes. OBJECTIVE: To determine whether FGFR3 mutations initiate BCa and impact BCa male sex bias. DESIGN, SETTING, AND PARTICIPANTS: We developed a transgenic mouse...
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