Inherited Germline Variants in Urinary Tract Cancer: A Multicenter Whole-Exome Sequencing Analysis and Correlation With Clinical Features and Tumor Genomics.

doi:10.1200/PO.23.00697

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Article

Inherited Germline Variants in Urinary Tract Cancer: A Multicenter Whole-Exome Sequencing Analysis and Correlation With Clinical Features and Tumor Genomics.

JCO precision oncology - 1 Jun 2024

Kohlmann Wendy, Nix David A, Pauley Kristen, Greenberg Samantha, Atkinson Aaron, Boucher Kenneth M, Kolesar Jill, Singer Eric A, Edge Stephen B, Churchman Michelle L, Graham Laura, Salhia Bodour, Sanchez Alejandro, Zakharia Yousef, Nepple Kenneth G, Schneider Bryan P, Byrne Lindsey, Jain Rohit K, Chahoud Jad, Feng Bing-Jian, Gupta Sumati

Abstract excerpt

PURPOSE: This study investigates a real-world multicenter cohort of patients with urinary tract cancer (UTC), with primary disease sites including the bladder, urethra, and upper tract, who enrolled for research molecular testing of their germline and tumor. The purpose of this study was to evaluate factors that could affect the likelihood of identifying a clinically actionable germline pathogenic variant (PV)....

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PMID: 38976819
DOI: 10.1200/PO.23.00697
PMCID: PMC11813167

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