Article

Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

2022-03-31

Abstract excerpt

Bladder cancer has a high recurrence rate and low survival of advanced stage patients. Few genetic drivers of bladder cancer have thus far been identified. We performed in-depth structural variant analysis on whole-genome sequencing data of 206 metastasized urinary tract cancers. In ˜10% of the patients, we identified recurrent in-frame deletions of exons 8 and 9 in the aryl hydrocarbon receptor gene ( AHR Δe8-9 )...

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Literature Corpus work: 5b892eaf-c7f9-5200-8bbb-655d224d5a23
DOI: 10.21203/rs.3.rs-1486740/v1

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