Article
Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing.
Oncotarget - 19 Jan 2016
Wu Song, Yang Zhao, Ye Rui, An Dan, Li Chong, Wang Yitian, Wang Yongqiang, Huang Yi, Liu Huan, Li Feida, He Luyun, Sun Da, Yu Yuan, Li Qiaoling, Huang Peide, Zhang Meng, Zhao Xin, Bi Tengteng, Zhuang Xuehan, Zhang Liyan, Lu Jingxiao, Sun Xiaojuan, Zhou Fangjian, Liu Chunxiao, Yang Guosheng, Hou Yong, Fan Zusen, Cai Zhiming
Abstract excerpt
Bladder cancer (BC) is distinguished by high rate of recurrence after surgery, but the underlying mechanisms remain poorly understood. Here we performed the whole-exome sequencing of 37 BC individuals including 20 primary and 17 recurrent samples in which the primary and recurrent samples were not from the same patient. We uncovered that MLL, EP400, PRDM2, ANK3 and CHD5 exclusively altered in recurrent BCs....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.