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Article

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer.

Genome medicine - 28 Sept 2020

Shi Ming-Jun, Meng Xiang-Yu, Fontugne Jacqueline, Chen Chun-Long, Radvanyi François, Bernard-Pierrot Isabelle

Abstract excerpt

BACKGROUND: APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only a few APOBEC-associated driver hotspot mutations have been identified in bladder cancer (BCa). Here, we systematically looked for and characterised...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32988402
DOI: 10.1186/s13073-020-00781-y
PMCID: PMC7646471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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