Article

Clinical and genomic profiling of early-onset bladder cancer identifies key alterations and therapeutic targets

2025-01-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Younger patients with bladder cancer typically have fewer environmental exposures or risk factors, suggesting that the molecular pathways implicated in early-onset disease differ from those in older patients. Dissecting the genomic profiles of early-onset tumors may inform targeted treatment strategies for young patients. We compared the frequency of somatic mutations in early-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5469197c-b1b8-5a0a-908f-b858eeae9376
DOI: 10.1101/2025.01.10.25320337

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical and genomic profiling of early-onset bladder cancer identifies key alterations and therapeutic targetsDOI 10.1101/2025.01.10.25320337Read

Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer.Semantic proximity Read

Mutation Hotspots Found in Bladder Cancer Aid Prediction of Carcinogenic Risk in Normal Urothelium.Semantic proximity Read

Molecular Profiling of Bladder Adenocarcinoma Using a National Genomics RepositorySemantic proximity Read

Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder†.Semantic proximity Read

Similar genetic profile in early and late stage urothelial tract cancer.Semantic proximity Read

The geriatrics and genetics behind bladder cancer.Semantic proximity Read

Bladder Cancer in the Genomic EraSemantic proximity Read

Genetic and Epigenetic Alterations in Bladder CancerSemantic proximity Read

Comprehensive genomic characterization of early-stage bladder cancer.Semantic proximity Read

A systematic review of genome-wide association studies on bladder cancerSemantic proximity Read

Frontiers in Bladder Cancer Genomic ResearchSemantic proximity Read

The evolution of bladder cancer genomics: What have we learned and how can we use it?Semantic proximity Read