Article

A Chemical Probe Based on the PreQ1 Metabolite Enables Transcriptome-wide Mapping of Binding Sites

2021-03-18

Abstract excerpt

<title>Abstract</title> <p>The role of metabolite-responsive riboswitches in regulating gene expression in bacteria is well known and makes them useful systems for the study of RNA-small molecule interactions. Here, we study the PreQ1 riboswitch system, assessing sixteen diverse PreQ1-derived probes for their ability to selectively modify the riboswitch aptamer covalently. For the most active probe, a diazirine-b...

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Literature Corpus work: d0e332e3-089f-536a-b41a-a89ba036a7ef
DOI: 10.21203/rs.3.rs-322220/v1

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