Article

Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule-RNA binding events in native cells

2024-11-14

Abstract excerpt

Splice modulating small molecules have been developed to promote the U1 snRNP to engage with pre-mRNAs with strong and altered sequence preference. Transcriptomic profiling of bulk RNA from compound treated cells enables detection of RNAs impacted; however, it is difficult to delineate whether transcriptional changes are a consequence of direct compound treatment or trans-acting effects. To identify RNA targets th...

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Literature Corpus work: 4d2122c1-1fb7-57e8-a2e7-9f272a214a91
DOI: 10.1101/2024.11.14.623654

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