Site-Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting.

Abstract excerpt

To facilitate the design of RNA-targeted covalent probes we report a bottom-up, structure-informed approach using mutational profiling. We designed a compact library of covalent probes based on the scaffold of Ribocil, a selective inhibitor targeting the bacterial FMN riboswitch and screened them against the FMN riboswitch aptamer from Fusobacterium nucleatum, Bacillus subtilis, Escherichia coli, and...

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