Article

Perturbation-Specific Transcriptional Mapping for unbiased target elucidation of antibiotics

2024-04-28

Abstract excerpt

The rising prevalence of antibiotic resistance threatens human health. While more sophisticated strategies for antibiotic discovery are being developed, target elucidation of new chemical entities remains challenging. In the post-genomic era, expression profiling can play an important role in mechanism-of-action (MOA) prediction by reporting on the cellular response to perturbation. However, the broad application...

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Literature Corpus work: e316c9a9-ce82-5ba4-9ea7-3911d896b683
DOI: 10.1101/2024.04.25.590978

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