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Article

Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells.

eLife - 29 Nov 2021

Behesti Hourinaz, Kocabas Arif, Buchholz David E, Carroll Thomas S, Hatten Mary E

Abstract excerpt

Brain development is regulated by conserved transcriptional programs across species, but little is known about the divergent mechanisms that create species-specific characteristics. Among brain regions, human cerebellar histogenesis differs in complexity compared with nonhuman primates and rodents, making it important to develop methods to generate human cerebellar neurons that closely resemble those in the...

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Identifiers

PMID: 34842137
DOI: 10.7554/eLife.67074
PMCID: PMC8687658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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