Article

Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation

2024-09-15

Abstract excerpt

We present a method for detecting evidence of natural selection in ancient DNA time-series data that leverages an opportunity not utilized in previous scans: testing for a consistent trend in allele frequency change over time. By applying this to 8433 West Eurasians who lived over the past 14000 years and 6510 contemporary people, we find an order of magnitude more genome-wide significant signals than previous stu...

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Literature Corpus work: bc17756d-4267-5ff5-8ae9-55b7ea58232c
DOI: 10.1101/2024.09.14.613021

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