Evolution of immune genes is associated with the Black Death.

doi:10.1038/s41586-022-05349-x

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Article

Evolution of immune genes is associated with the Black Death.

Nature - 1 Nov 2022

Klunk Jennifer, Vilgalys Tauras P, Demeure Christian E, Cheng Xiaoheng, Shiratori Mari, Madej Julien, Beau Rémi, Elli Derek, Patino Maria I, Redfern Rebecca, DeWitte Sharon N, Gamble Julia A, Boldsen Jesper L, Carmichael Ann, Varlik Nükhet, Eaton Katherine, Grenier Jean-Christophe, Golding G Brian, Devault Alison, Rouillard Jean-Marie, Yotova Vania, Sindeaux Renata, Ye Chun Jimmie, Bikaran Matin, Dumaine Anne, Brinkworth Jessica F, Missiakas Dominique, Rouleau Guy A, Steinrücken Matthias, Pizarro-Cerdá Javier, Poinar Hendrik N, Barreiro Luis B

Abstract excerpt

Infectious diseases are among the strongest selective pressures driving human evolution1,2. This includes the single greatest mortality event in recorded history, the first outbreak of the second pandemic of plague, commonly called the Black Death, which was caused by the bacterium Yersinia pestis3. This pandemic devastated Afro-Eurasia, killing up to 30-50% of the population4. To identify loci that may have been...

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PMID: 36261521
DOI: 10.1038/s41586-022-05349-x
PMCID: PMC9580435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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