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Article

Human immune diversity: from evolution to modernity.

Nature immunology - 1 Dec 2021

Liston Adrian, Humblet-Baron Stephanie, Duffy Darragh, Goris An

Abstract excerpt

The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, provides a potent defense against opportunistic pathogens. At the same time, this immune variation is the substrate upon which a plethora of immune-associated diseases develop. Genetic analysis suggests that thousands of individually weak loci together drive up to half of the observed immune variation. Intense...

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PMID: 34795445
DOI: 10.1038/s41590-021-01058-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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