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Article

Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.

The Journal of infectious diseases - 15 Jul 2012

Mejia Ana Maria, Hall Belinda S, Taylor Martin C, Gómez-Palacio Andrés, Wilkinson Shane R, Triana-Chávez Omar, Kelly John M

Abstract excerpt

Benznidazole is the frontline drug used against Trypanosoma cruzi, the causative agent of Chagas disease. However, treatment failures are often reported. Here, we demonstrate that independently acquired mutations in the gene encoding a mitochondrial nitroreductase (TcNTR) can give rise to distinct drug-resistant clones within a single population. Following selection of benznidazole-resistant parasites, all clones...

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Identifiers

PMID: 22551809
DOI: 10.1093/infdis/jis331
PMCID: PMC3379838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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