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Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

22 May 2023

Abstract excerpt

BACKGROUND: Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a serious public health concern in Latin America. Nifurtimox and benznidazole (BZ), the only two drugs currently approved for the treatment of CD, have very low efficacies in the chronic phase of the disease and several toxic side effects. Trypanosoma cruzi strains that are naturally resistant to both drugs have been reported. We...

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PMID: 37217925
DOI: 10.1186/s13071-023-05775-4

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