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Article

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.

The Journal of antimicrobial chemotherapy - 1 Mar 2016

Wyllie Susan, Foth Bernardo J, Kelner Anna, Sokolova Antoaneta Y, Berriman Matthew, Fairlamb Alan H

Abstract excerpt

OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by stepwise exposure to increasing drug concentrations. Clones were subjected to WGS to identify putative resistance genes. Transgenic parasites modulating expression of...

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Source

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Identifiers

PMID: 26581221
DOI: 10.1093/jac/dkv376
PMCID: PMC4743696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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