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Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert

1 Jan 2014

Abstract excerpt

Benznidazole is the main drug used to treat Trypanosoma cruzi infections. However, frequent instances of treatment failure have been reported. To better understand potential resistance mechanisms, we analysed three clones isolated from a single parasite population that had undergone benznidazole-selection. These clones exhibited differing levels of benznidazole-resistance (varying between 9 and 26-fold), and...

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PMID: 24462750
DOI: 10.1016/j.molbiopara.2014.01.002

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