Article
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Scientific reports - 31 Oct 2017
Campos Mônica C, Phelan Jody, Francisco Amanda F, Taylor Martin C, Lewis Michael D, Pain Arnab, Clark Taane G, Kelly John M
Abstract excerpt
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 5-8 million people in Latin America. Although the nitroheterocyclic compound benznidazole has been the front-line drug for several decades, treatment failures are common. Benznidazole is a pro-drug and is bio-activated within the parasite by the mitochondrial nitroreductase TcNTR-1, leading to the generation of reactive metabolites...
Topics
- Animals
- Chagas Disease
- Disease Models, Animal
- Drug Resistance, Multiple
- Female
- Genome, Protozoan
- Mice, SCID
- Mutagenesis
- Mutagens
- Mutation
- Nitroimidazoles