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Article

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.

Scientific reports - 31 Oct 2017

Campos Mônica C, Phelan Jody, Francisco Amanda F, Taylor Martin C, Lewis Michael D, Pain Arnab, Clark Taane G, Kelly John M

Abstract excerpt

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 5-8 million people in Latin America. Although the nitroheterocyclic compound benznidazole has been the front-line drug for several decades, treatment failures are common. Benznidazole is a pro-drug and is bio-activated within the parasite by the mitochondrial nitroreductase TcNTR-1, leading to the generation of reactive metabolites...

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Identifiers

PMID: 29089615
DOI: 10.1038/s41598-017-14986-6
PMCID: PMC5663738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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