Article

Predictive design of tissue-specific mammalian enhancers that function <i>in vivo</i> in the mouse embryo

2025-12-24

Abstract excerpt

<h4>Summary</h4> Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains unclear whether such approaches can operate within the regulatory complexity of mammalian tissues in vivo. Here, we present a general strategy for designing tissue-specific enhancers that function reliabl...

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Literature Corpus work: b1cb7b45-e80a-5f37-bf69-bbfdf3bc432d
DOI: 10.64898/2025.12.22.695948

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