Article

Genome-wide active enhancer identification using cell type-specific signatures of epigenomic activity

2018-09-20

Abstract excerpt

Recently enhancers have emerged as key players regulating crucial mechanisms such as cell fate determination and establishment of spatiotemporal patterns of gene expression during development. Due to their functional and structural complexity, an accurate in silico identification of active enhancers under specific conditions remain challenging. We present a novel machine learning based method that derives epigeno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be95e449-6ea3-5ca9-90dc-0393cf4868e2
DOI: 10.1101/421230

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide active enhancer identification using cell type-specific signatures of epigenomic activityDOI 10.1101/421230Read

An extensive enhancer-promoter map generated by genome-scale analysis of enhancer and gene activity patternsSemantic proximity Read

EAGLE: an algorithm that utilizes a small number of genomic features to predict tissue/cell type-specific enhancer-gene interactionsSemantic proximity Read

EnhancerTracker: Comparing cell-type-specific enhancer activity of DNA sequence triplets via an ensemble of deep convolutional neural networksSemantic proximity Read

An atlas of active enhancers across human cell types and tissues.Semantic proximity Read

Uncovering Hidden Enhancers Through Unbiased <i>In Vivo</i> TestingSemantic proximity Read

A cross-organism framework for supervised enhancer prediction with epigenetic pattern recognition and targeted validationSemantic proximity Read

Explainable AI identifies H3K18ac as a new marker of active enhancersSemantic proximity Read

Motif signatures of transcribed enhancersSemantic proximity Read

A semi-supervised approach uncovers thousands of intragenic enhancers differentially activated in human cellsSemantic proximity Read

Genome-wide Enhancer Maps Differ Significantly in Genomic Distribution, Evolution, and FunctionSemantic proximity Read

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient SamplesSemantic proximity Read

Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysisSemantic proximity Read