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Article

Interstrain recombinants of human cytomegalovirus uncouple glycoprotein display, virion infectivity, and spread characteristics.

Journal of virology - 17 Feb 2026

Peterson Christopher S, Bailey Ian T, Lanchy Jean-Marc, Gallego Ivan, Ryckman Brent J

Abstract excerpt

A prevailing model holds that human cytomegalovirus (HCMV) spreads cell-to-cell spread upon initial culturing from clinical specimens and that de novo mutations in the UL128-131 genes reduce expression of glycoprotein complex gH/gL/UL128-131 (pentamer) relative to gH/gL/gO (trimer), which in turn enhances virion infectivity and favors cell-free spread. The clone Merlin-BAC (ME) expresses far more pentamer than...

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Identifiers

PMID: 41467839
DOI: 10.1128/jvi.01592-25
PMCID: PMC12911907

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