Article

ASPM induces radiotherapy resistance by disrupting microtubule stability leading to chromosome malsegregation in non-small cell lung cancer

2022-09-29

Abstract excerpt

<title>Abstract</title> <p>Radiotherapy (RT) resistance remains a substantial challenge in cancer therapy. Although physical factors are optimizing, the biological mechanisms for RT resistance are still elusive. Herein, we explored potential reasons for this difficult problem by generating RT-resistant models for <italic>in vitro</italic> and <italic>in vivo</italic> experiments. We found that abnormal spindle-li...

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Literature Corpus work: d0a2f937-d9db-5f9a-b684-a8335c487c07
DOI: 10.21203/rs.3.rs-2091604/v1

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